[Immunization with live attenuated A/H5N1 vaccine protects guinea pigs from reinfection].
Identifieur interne : 002E13 ( Main/Exploration ); précédent : 002E12; suivant : 002E14[Immunization with live attenuated A/H5N1 vaccine protects guinea pigs from reinfection].
Auteurs : M V Sergeeva ; V V Kuznetsov ; M A Kas'Ianenko ; A A Shaldzhian ; I A Repko ; M V Potapchuk ; Iu R. Romanova ; L M TsybalovaSource :
- Voprosy virusologii [ 0507-4088 ]
Descripteurs français
- KwdFr :
- Adaptation biologique, Animaux, Anticorps antiviraux (immunologie), Anticorps antiviraux (sang), Basse température, Cochons d'Inde, Immunisation, Immunité muqueuse, Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (immunologie), Infections à Orthomyxoviridae (virologie), Muqueuse respiratoire (immunologie), Muqueuse respiratoire (virologie), Sialidase (génétique), Sialidase (immunologie), Sous-type H2N2 du virus de la grippe A (génétique), Sous-type H2N2 du virus de la grippe A (immunologie), Sous-type H5N1 du virus de la grippe A (génétique), Sous-type H5N1 du virus de la grippe A (immunologie), Tests de neutralisation, Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (immunologie), Vaccins atténués, Virus recombinants (génétique), Virus recombinants (immunologie).
- MESH :
- administration et posologie : Vaccins antigrippaux.
- génétique : Sialidase, Sous-type H2N2 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A, Virus recombinants.
- immunologie : Anticorps antiviraux, Infections à Orthomyxoviridae, Muqueuse respiratoire, Sialidase, Sous-type H2N2 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A, Vaccins antigrippaux, Virus recombinants.
- sang : Anticorps antiviraux.
- virologie : Infections à Orthomyxoviridae, Muqueuse respiratoire.
- Adaptation biologique, Animaux, Basse température, Cochons d'Inde, Immunisation, Immunité muqueuse, Infections à Orthomyxoviridae, Tests de neutralisation, Vaccins atténués.
English descriptors
- KwdEn :
- Adaptation, Biological, Animals, Antibodies, Viral (blood), Antibodies, Viral (immunology), Cold Temperature, Guinea Pigs, Immunity, Mucosal, Immunization, Influenza A Virus, H2N2 Subtype (genetics), Influenza A Virus, H2N2 Subtype (immunology), Influenza A Virus, H5N1 Subtype (genetics), Influenza A Virus, H5N1 Subtype (immunology), Influenza Vaccines (administration & dosage), Influenza Vaccines (immunology), Neuraminidase (genetics), Neuraminidase (immunology), Neutralization Tests, Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (prevention & control), Orthomyxoviridae Infections (virology), Reassortant Viruses (genetics), Reassortant Viruses (immunology), Respiratory Mucosa (immunology), Respiratory Mucosa (virology), Vaccines, Attenuated.
- MESH :
- chemical , administration & dosage : Influenza Vaccines.
- chemical , blood : Antibodies, Viral.
- chemical , genetics : Neuraminidase.
- chemical , immunology : Antibodies, Viral, Influenza Vaccines, Neuraminidase.
- genetics : Influenza A Virus, H2N2 Subtype, Influenza A Virus, H5N1 Subtype, Reassortant Viruses.
- immunology : Influenza A Virus, H2N2 Subtype, Influenza A Virus, H5N1 Subtype, Orthomyxoviridae Infections, Reassortant Viruses, Respiratory Mucosa.
- prevention & control : Orthomyxoviridae Infections.
- virology : Orthomyxoviridae Infections, Respiratory Mucosa.
- Adaptation, Biological, Animals, Cold Temperature, Guinea Pigs, Immunity, Mucosal, Immunization, Neutralization Tests, Vaccines, Attenuated.
Abstract
Cold-adapted influenza virus A/HK/1/68/162/35(H3N2) was developed as unified donor of attenuation and high reproductive capacity forvaccine strains. The reassortant of this donor with surface antigens of highly pathogenic strain Alchicken/Astana/6/05 (H5N1) was tested in guinea pigs as a live or inactivated preparation. Immunization with both formulations induced equal levels of serum virus specific antibodies, while the level of mucosal antibodies was significantly higher in animals immunized with live virus. The challenge with the homologous virus demonstrated complete virus clearance only in this group, thereby indicating a direct correlation of the protection level with the level of mucosal antibodies.
PubMed: 24772645
Affiliations:
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Le document en format XML
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Romanova</name></author><author><name sortKey="Tsybalova, L M" sort="Tsybalova, L M" uniqKey="Tsybalova L" first="L M" last="Tsybalova">L M Tsybalova</name></author></analytic><series><title level="j">Voprosy virusologii</title><idno type="ISSN">0507-4088</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptation, Biological</term><term>Animals</term><term>Antibodies, Viral (blood)</term><term>Antibodies, Viral (immunology)</term><term>Cold Temperature</term><term>Guinea Pigs</term><term>Immunity, Mucosal</term><term>Immunization</term><term>Influenza A Virus, H2N2 Subtype (genetics)</term><term>Influenza A Virus, H2N2 Subtype (immunology)</term><term>Influenza A Virus, H5N1 Subtype (genetics)</term><term>Influenza A Virus, H5N1 Subtype (immunology)</term><term>Influenza Vaccines (administration & dosage)</term><term>Influenza Vaccines (immunology)</term><term>Neuraminidase (genetics)</term><term>Neuraminidase (immunology)</term><term>Neutralization Tests</term><term>Orthomyxoviridae Infections (immunology)</term><term>Orthomyxoviridae Infections (prevention & control)</term><term>Orthomyxoviridae Infections (virology)</term><term>Reassortant Viruses (genetics)</term><term>Reassortant Viruses (immunology)</term><term>Respiratory Mucosa (immunology)</term><term>Respiratory Mucosa (virology)</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adaptation biologique</term><term>Animaux</term><term>Anticorps antiviraux (immunologie)</term><term>Anticorps antiviraux (sang)</term><term>Basse température</term><term>Cochons d'Inde</term><term>Immunisation</term><term>Immunité muqueuse</term><term>Infections à Orthomyxoviridae ()</term><term>Infections à Orthomyxoviridae (immunologie)</term><term>Infections à Orthomyxoviridae (virologie)</term><term>Muqueuse respiratoire (immunologie)</term><term>Muqueuse respiratoire (virologie)</term><term>Sialidase (génétique)</term><term>Sialidase (immunologie)</term><term>Sous-type H2N2 du virus de la grippe A (génétique)</term><term>Sous-type H2N2 du virus de la grippe A (immunologie)</term><term>Sous-type H5N1 du virus de la grippe A (génétique)</term><term>Sous-type H5N1 du virus de la grippe A (immunologie)</term><term>Tests de neutralisation</term><term>Vaccins antigrippaux (administration et posologie)</term><term>Vaccins antigrippaux (immunologie)</term><term>Vaccins atténués</term><term>Virus recombinants (génétique)</term><term>Virus recombinants (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Neuraminidase</term></keywords><keywords scheme="MESH" type="chemical" 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Mucosal</term><term>Immunization</term><term>Neutralization Tests</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adaptation biologique</term><term>Animaux</term><term>Basse température</term><term>Cochons d'Inde</term><term>Immunisation</term><term>Immunité muqueuse</term><term>Infections à Orthomyxoviridae</term><term>Tests de neutralisation</term><term>Vaccins atténués</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cold-adapted influenza virus A/HK/1/68/162/35(H3N2) was developed as unified donor of attenuation and high reproductive capacity forvaccine strains. The reassortant of this donor with surface antigens of highly pathogenic strain Alchicken/Astana/6/05 (H5N1) was tested in guinea pigs as a live or inactivated preparation. Immunization with both formulations induced equal levels of serum virus specific antibodies, while the level of mucosal antibodies was significantly higher in animals immunized with live virus. The challenge with the homologous virus demonstrated complete virus clearance only in this group, thereby indicating a direct correlation of the protection level with the level of mucosal antibodies.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Kas Ianenko, M A" sort="Kas Ianenko, M A" uniqKey="Kas Ianenko M" first="M A" last="Kas'Ianenko">M A Kas'Ianenko</name><name sortKey="Kuznetsov, V V" sort="Kuznetsov, V V" uniqKey="Kuznetsov V" first="V V" last="Kuznetsov">V V Kuznetsov</name><name sortKey="Potapchuk, M V" sort="Potapchuk, M V" uniqKey="Potapchuk M" first="M V" last="Potapchuk">M V Potapchuk</name><name sortKey="Repko, I A" sort="Repko, I A" uniqKey="Repko I" first="I A" last="Repko">I A Repko</name><name sortKey="Romanova, Iu R" sort="Romanova, Iu R" uniqKey="Romanova I" first="Iu R" last="Romanova">Iu R. Romanova</name><name sortKey="Sergeeva, M V" sort="Sergeeva, M V" uniqKey="Sergeeva M" first="M V" last="Sergeeva">M V Sergeeva</name><name sortKey="Shaldzhian, A A" sort="Shaldzhian, A A" uniqKey="Shaldzhian A" first="A A" last="Shaldzhian">A A Shaldzhian</name><name sortKey="Tsybalova, L M" sort="Tsybalova, L M" uniqKey="Tsybalova L" first="L M" last="Tsybalova">L M Tsybalova</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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